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Successful treatment of primary Sjögren's syndrome with chronic natural killer lymphocytosis by high-dose prednisolone and indomethacin farnesil.

Abstract
We report a patient with Sjögren's syndrome and chronic natural killer lymphocytosis, who developed severe neutropenia, autoimmune hemolytic anemia, and immune thrombocytopenia. High-dose prednisolone therapy improved the hemolytic anemia and thrombocytopenia, but not the CD16(+) CD56(-) NK lymphocytosis completely. Interestingly, indomethacin farnesil (a prodrug of indomethacin) was effective for myalgia and also decreased the number of CD16(+) CD56(-) NK cells. NK lymphocytosis is rarely associated with autoimmune disease, but the combination of indomethacin and steroid therapy may have a favorable effect for such patients.
AuthorsYoshimasa Fujita, Takao Fujii, Naho Takeda, Masao Tanaka, Tsuneyo Mimori
JournalInternal medicine (Tokyo, Japan) (Intern Med) Vol. 46 Issue 5 Pg. 251-4 ( 2007) ISSN: 1349-7235 [Electronic] Japan
PMID17329922 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Glucocorticoids
  • Prednisolone
  • indomethacin farnesil
  • Indomethacin
Topics
  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
  • Chronic Disease
  • Female
  • Glucocorticoids (therapeutic use)
  • Humans
  • Indomethacin (analogs & derivatives, therapeutic use)
  • Killer Cells, Natural (pathology)
  • Lymphocytosis (etiology, pathology)
  • Prednisolone (therapeutic use)
  • Sialadenitis (etiology, pathology)
  • Sjogren's Syndrome (complications, drug therapy)
  • Treatment Outcome

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