Cerebral protective and cognition-improving effects of sinapic acid in rodents.

Abstract

We previously demonstrated that tenuifoliside B and 3,6'-disinapoylsucrose in Polygalae Radix, the root of Polygala tenuifolia WILLDENOW, inhibited potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment in mice. Because both ingredients have a common sinapoyl moiety in their structure, we inferred that the sinapoyl moiety could inhibit hypoxia and memory impairment. In the present study to clarify the hypothesis, sinapic acid inhibited KCN-induced hypoxia and scopolamine-induced memory impairment as well as tenuifoliside B and 3,6'-disinapoylsucrose did. In addition, sinapic acid inhibited decompression- or bilateral carotid artery ligation-induced hypoxia (or mortality) and CO2-induced impairment in mice, and basal forebrain lesion-induced cerebral cholinergic dysfunction (decreases in acetylcholine concentration and choline acetyltransferase activity) in rats. These results, taken together, suggest the possibilities that sinapic acid is not only a very important moiety in the pharmacological activities of tenuifoliside B and 3,6'-disinapoylsucrose but also a candidate for a cerebral protective and cognition-improving medicine.

• Authors: Fumito Karakida, Yukinobu Ikeya, Mitsuo Tsunakawa, Takuji Yamaguchi, Yasushi Ikarashi, Shuichi Takeda, Masaki Aburada
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 30 Issue 3 Pg. 514-9 (Mar 2007) ISSN: 0918-6158 [Print] Japan
• PMID: 17329848 (Publication Type: Journal Article)

Chemical References

• Coumaric Acids
• Excitatory Amino Acid Agonists
• Neuroprotective Agents
• Carbon Dioxide
• Ibotenic Acid
• sinapinic acid
• Scopolamine
• Potassium Cyanide
• Acetylcholine

Topics

• Acetylcholine (metabolism)
• Amnesia (chemically induced, prevention & control)
• Animals
• Carbon Dioxide (administration & dosage, toxicity)
• Cognition (drug effects, physiology)
• Coma (chemically induced, prevention & control)
• Coumaric Acids (administration & dosage, pharmacology)
• Dose-Response Relationship, Drug
• Excitatory Amino Acid Agonists (administration & dosage, toxicity)
• Frontal Lobe (drug effects, metabolism, physiopathology)
• Hypoxia (etiology, prevention & control)
• Ibotenic Acid (administration & dosage, toxicity)
• Male
• Medicine, Kampo
• Memory Disorders (physiopathology, prevention & control)
• Mice
• Mice, Inbred ICR
• Neuroprotective Agents (administration & dosage, pharmacology)
• Parietal Lobe (drug effects, metabolism, physiopathology)
• Potassium Cyanide (administration & dosage, toxicity)
• Rats
• Rats, Wistar
• Scopolamine (administration & dosage, toxicity)
• Survival Rate