T-cell recognition of Paracoccidioides brasiliensis gp43-derived peptides in patients with paracoccidioidomycosis and healthy individuals.

Abstract

Vaccines with synthetic peptides induce the immune response to epitopes that bind to several HLA alleles. By using a TEPITOPE algorithm, we selected and analyzed the T-cell responses of peripheral blood mononuclear cells from 29 paracoccidioidomycosis (PCM) patients to peptides of the immunodominant gp43 antigen of Paracoccidioides brasiliensis, the causative agent of PCM.

• Authors: Leo Kei Iwai, Márcia Yoshida, Aya Sadahiro, Washington Robert da Silva, Maria Lucia Marin, Anna Carla Goldberg, Maria Aparecida Juliano, Luiz Juliano, Maria Aparecida Shikanai-Yasuda, Jorge Kalil, Edecio Cunha-Neto, Luiz R Travassos
• Journal: Clinical and vaccine immunology : CVI (Clin Vaccine Immunol) Vol. 14 Issue 4 Pg. 474-6 (Apr 2007) ISSN: 1556-6811 [Print] United States
• PMID: 17329443 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 43 kDa protein, Paracoccidioides
• Antigens, Fungal
• Fungal Proteins
• Glycoproteins
• Peptides

Topics

• Antigens, Fungal (immunology)
• Cells, Cultured
• Fungal Proteins (immunology)
• Glycoproteins (immunology)
• Humans
• Paracoccidioides (immunology)
• Paracoccidioidomycosis (immunology, microbiology)
• Peptides (immunology)
• T-Lymphocytes (immunology, microbiology)