The comparative clinical performance of a new polyhexamethylene biguanide- vs a polyquad-based contact lens care regime with two silicone hydrogel contact lenses.

Abstract

PURPOSE:

To compare the clinical performance of a new polyhexamethylene-biguanide (PHMB)- vs a polyquad-based contact lens care regime with two silicone hydrogel contact lenses.

METHODS:

This study was a randomised, controlled and investigator-masked (to the lens regimen) clinical study where the clinical performance of two multipurpose contact lens solutions was compared at a single site. Forty-one existing contact lens wearers were recruited and fitted randomly with either galyfilcon A or lotrafilcon A contact lenses. Subjects wore the same lens type for a period of 2 months but used a different care regime (PHMB- and polyquad-based) in a crossover manner, each for a period of 1 month. The primary outcome measure was the difference in corneal staining. Corneal staining was graded in five different locations: central, superior, inferior, temporal and nasal. Measurements of conjunctival redness, limbal redness, conjunctival staining and papillary conjunctivitis were also carried out throughout the study. Biomicroscopic measures were graded using the Efron grading scales. A variety of symptoms were also measured using a visual analogue scale.

RESULTS:

There was no statistically significant difference in overall corneal staining between lens types (p = 0.16) or care regimens (p = 0.60). Central corneal staining was significantly greater for the polyquad-based care regimen when compared with the PHMB-based care regimen (p = 0.04). Lotrafilcon A lenses showed greater superior corneal staining (p = 0.0004) and papillary conjunctivitis (p = 0.02), and lower comfort on insertion (p = 0.03) when compared with galyfilcon A lenses regardless of the care regime used. There were no statistically significant differences in the other biomicrosopic signs and symptoms between the lens types and the care regimes.

CONCLUSIONS:

Both care regimes performed in a similar clinical manner and are valid for use with the two silicone hydrogel contact lenses used in this study.

• Authors: Jacinto Santodomingo-Rubido
• Journal: Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) (Ophthalmic Physiol Opt) Vol. 27 Issue 2 Pg. 168-73 (Mar 2007) ISSN: 0275-5408 [Print] England
• PMID: 17324206 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Biguanides
• Contact Lens Solutions
• Disinfectants
• Hydrogels
• Polymers
• Silicone Gels
• polihexanide
• polyquaternium 1

Topics

• Adolescent
• Adult
• Biguanides
• Contact Lens Solutions (adverse effects)
• Contact Lenses
• Disinfectants
• Humans
• Hydrogels
• Middle Aged
• Patient Satisfaction
• Polymers
• Silicone Gels