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Total structure and inhibition of tumor cell proliferation of laxaphycins.

Abstract
From a mixed assemblage of Lyngbya majuscula rich marine cyanobacteria, we isolated a series of cell growth inhibitory cyclic peptides. The structures of the two major components, laxaphycins A (1) and B (2), and of two minor peptides, laxaphycins B2 (3) and B3 (4), were determined by spectroscopic methods and degradative analysis. Absolute configurations of natural and nonproteinogenic amino acids were determined by a combination of hydrolysis, synthesis of noncommercial residues, chemical derivatization, and HPLC analysis. The organism producing the laxaphycins was identified as the cyanobacterium Anabaena torulosa. The antiproliferative activity of laxaphycins was investigated on a panel of solid and lymphoblastic cancer cells. Our results demonstrate that in contrast to laxaphycin A, laxaphycin B inhibits the proliferation of sensitive and resistant human cancer cell lines and that this activity is strongly increased in the presence of laxaphycin A. This effect appears to be due to an unusual biological synergism.
AuthorsIsabelle Bonnard, Marc Rolland, Jean-Marie Salmon, Eric Debiton, Chantal Barthomeuf, Bernard Banaigs
JournalJournal of medicinal chemistry (J Med Chem) Vol. 50 Issue 6 Pg. 1266-79 (Mar 22 2007) ISSN: 0022-2623 [Print] United States
PMID17323939 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Laxaphycin A
  • Laxaphycin B
  • Peptides, Cyclic
  • laxaphycin B2
  • laxaphycin B3
Topics
  • Anabaena (chemistry)
  • Animals
  • Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
  • Cell Line
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Chromatography, High Pressure Liquid
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Drug Screening Assays, Antitumor
  • Drug Synergism
  • Humans
  • Hydrolysis
  • Magnetic Resonance Spectroscopy
  • Mice
  • Peptides, Cyclic (chemistry, isolation & purification, pharmacology)
  • Structure-Activity Relationship

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