Cerebrospinal fluid anti-cerebellar soluble lectin antibodies in human immunodeficiency virus type 1 infection.

Abstract

Cerebrospinal fluid samples from 14 human immunodeficiency type 1 (HIV-1) seropositive patients in various stages of HIV infection were tested for the presence of autoantibodies to an endogenous manose-binding protein, the cerebellar soluble lectin (CSL), which has recently been found to be detected in a high proportion of patients with multiple sclerosis. An immunoblotting test was used with rat CSL as antigen. Seven patients were positive for anti-CSL and seven were negative. The seven anti-CSL-positive patients had signs of intrathecal immunoglobulin G production measured as an elevated IgG index, while the seven anti-CSL-negative patients had a normal IgG index. There was no apparent relation between infectious stage and the presence of anti-CSL. Immunological reactions such as anti-CSL autoantibodies may be a similar pathogenic mechanism in HIV and multiple sclerosis brain disease.

• Authors: L Hagberg, G Norkrans, J P Zanetta, S Lehmann, T Bergström
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 36 Issue 2-3 Pg. 245-9 (Feb 1992) ISSN: 0165-5728 [Print] Netherlands
• PMID: 1732284 (Publication Type: Journal Article)

Chemical References

• Autoantibodies
• Lectins

Topics

• Acquired Immunodeficiency Syndrome (cerebrospinal fluid, immunology)
• Adult
• Autoantibodies (cerebrospinal fluid)
• Cerebellum (immunology)
• Female
• HIV-1
• Humans
• Lectins (immunology)
• Male
• Middle Aged