Abstract |
The 5-HT(1A) receptor agonist 8-OH-DPAT (0.5mg/kg) enhances behavioral recovery when administered 15min after experimental traumatic brain injury (TBI). To determine if benefits are still attainable at clinically relevant times, treatment was delayed 1 and 2h post-TBI and motor/cognitive performance was compared to early (i.e., 15min) administration. No differences were observed among the vehicle and 8-OH-DPAT groups treated at 1 and 2h, but all three were significantly impaired versus early 8-OH-DPAT. The data suggest that an early and narrow critical period exists for the behavioral recovery afforded by a single 8-OH-DPAT treatment paradigm. The critical window corresponds to the well documented TBI-induced glutamate increase, suggesting that 8-OH-DPAT may be conferring neuroprotection by attenuating this acute deleterious surge.
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Authors | Jeffrey P Cheng, Haris A Aslam, Ann N Hoffman, Ross D Zafonte, Anthony E Kline |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 416
Issue 2
Pg. 165-8
(Apr 12 2007)
ISSN: 0304-3940 [Print] Ireland |
PMID | 17321680
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Serotonin Receptor Agonists
- 8-Hydroxy-2-(di-n-propylamino)tetralin
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Topics |
- 8-Hydroxy-2-(di-n-propylamino)tetralin
(administration & dosage)
- Animals
- Behavior, Animal
(drug effects)
- Brain Injuries
(drug therapy)
- Male
- Maze Learning
(drug effects)
- Motor Activity
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Serotonin Receptor Agonists
(administration & dosage)
- Time Factors
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