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Anti-inflammatory and analgesic effects of the sesquiterpene lactone budlein A in mice: inhibition of cytokine production-dependent mechanism.

Abstract
The anti-inflammatory activities of some medicinal plants are attributed to their contents of sesquiterpene lactones. In the present study, the anti-inflammatory and anti-nociceptive activity of a sesquiterpene lactone isolated from Viguiera robusta, budlein A in mice was investigated. The treatment with budlein A dose--(1.0-10.0 mg/kg, p.o., respectively) dependently inhibited the carrageenan-induced: i. neutrophil migration to the peritoneal cavity (2-52%), ii. neutrophil migration to the paw skin tissue (32-74%), iii. paw oedema (13-74%) and iv. mechanical hypernociception (2-58%) as well as the acetic acid-induced writhings (0-66%). Additionally, budlein A (10.0 mg/kg) treatment inhibited the mechanical hypernociception-induced by tumour necrosis factor (TNF-alpha, 36%), Keratinocyte-derived chemokine (KC, 37%) and Interleukin-1beta (IL-1beta, 28%), but not of prostaglandin E(2) or dopamine. Budlein A also inhibited the carrageenan-induced release of TNF-alpha (52%), KC (70%) and IL-1beta (59%). Furthermore, an 8 days treatment with budlein A inhibited Complete Freund's adjuvant (10 microl/paw)-induced hypernociception, paw oedema and paw skin myeloperoxidase activity increase while not affecting the motor performance or myeloperoxidase activity in the stomach. Concluding, the present data suggest that budlein A presents anti-inflammatory and antinociceptive property in mice by a mechanism dependent on inhibition of cytokines production. It supports the potential beneficial effect of orally administered budlein A in inflammatory diseases involving cytokine-mediated nociception, oedema and neutrophil migration.
AuthorsDaniel A R Valério, Thiago M Cunha, Nilton S Arakawa, Henrique P Lemos, Fernando B Da Costa, Carlos A Parada, Sergio H Ferreira, Fernando Q Cunha, Waldiceu A Verri Jr
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 562 Issue 1-2 Pg. 155-63 (May 07 2007) ISSN: 0014-2999 [Print] Netherlands
PMID17320857 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Analgesics
  • Anti-Inflammatory Agents
  • Cytokines
  • Lactones
  • Sesquiterpenes
  • budlein A
  • Carrageenan
  • Freund's Adjuvant
  • Dinoprostone
  • Dopamine
Topics
  • Analgesics (chemistry, pharmacology)
  • Animals
  • Anti-Inflammatory Agents (chemistry, pharmacology)
  • Asteraceae (chemistry)
  • Behavior, Animal (drug effects)
  • Carrageenan (toxicity)
  • Cell Movement (drug effects)
  • Cytokines (metabolism)
  • Dinoprostone (toxicity)
  • Dopamine (toxicity)
  • Dose-Response Relationship, Drug
  • Edema (chemically induced, prevention & control)
  • Freund's Adjuvant (toxicity)
  • Hindlimb (drug effects, metabolism, pathology)
  • Inflammation (chemically induced, prevention & control)
  • Lactones (chemistry, pharmacology)
  • Male
  • Mice
  • Molecular Structure
  • Neutrophils (drug effects, pathology)
  • Pain (chemically induced, physiopathology, prevention & control)
  • Peritoneal Cavity (pathology)
  • Sesquiterpenes (chemistry, pharmacology)
  • Signal Transduction (drug effects)
  • Skin (drug effects, metabolism, pathology)

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