Abstract |
To evaluate variations in amyloid beta (Abeta) peptide pattern in cerebrospinal fluid (CSF) in neurodegenerative disorders. A recently established quantitative urea-based Abeta- sodium-dodecylsulfate- polyacrylamide-gel-electrophoresis with western immunoblot (Abeta-SDS-PAGE/immunoblot) revealed a highly conserved Abeta peptide (Abeta1-37, 1-38, 1-39, 1-40, 1-42) pattern in CSF. We asked whether the variation might be useful to further elucidate the overlap between or distinctions among neurodegenerative diseases in Abeta-processing. We used the Abeta-SDS-PAGE/immunoblot to investigate CSF for disease-specific Abeta peptide patterns. CSF samples from 96 patients with mainly clinically diagnosed Alzheimer's disease (n = 15), progressive supranuclear palsy (n = 20), corticobasal degeneration (n = 12), Parkinson's disease (n = 11), multiple systems atrophy (n = 18), and dementia with Lewy-bodies (n = 20) were analysed as well a comparison group (n = 19). The Abeta peptide patterns varied between tauopathies and synucleinopathies and between all diseases and the comparison group, possibly due to the influence of tau and alpha-synuclein on Abeta-processing.
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Authors | B Mollenhauer, M Bibl, H Esselmann, P Steinacker, C Trenkwalder, J Wiltfang, M Otto |
Journal | Journal of neural transmission (Vienna, Austria : 1996)
(J Neural Transm (Vienna))
Vol. 114
Issue 7
Pg. 919-27
(Jul 2007)
ISSN: 1435-1463 [Electronic] Austria |
PMID | 17318305
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Amyloid beta-Peptides
- alpha-Synuclein
- tau Proteins
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Topics |
- Aged
- Aged, 80 and over
- Alzheimer Disease
(cerebrospinal fluid, etiology, pathology)
- Amyloid beta-Peptides
(biosynthesis, cerebrospinal fluid, metabolism)
- Female
- Humans
- Male
- Middle Aged
- Multiple System Atrophy
(cerebrospinal fluid, etiology, pathology)
- Protein Processing, Post-Translational
- Tauopathies
(cerebrospinal fluid, etiology, pathology)
- alpha-Synuclein
(cerebrospinal fluid, physiology)
- tau Proteins
(cerebrospinal fluid, physiology)
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