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Tauopathies and synucleinopathies: do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis?

Abstract
To evaluate variations in amyloid beta (Abeta) peptide pattern in cerebrospinal fluid (CSF) in neurodegenerative disorders. A recently established quantitative urea-based Abeta-sodium-dodecylsulfate-polyacrylamide-gel-electrophoresis with western immunoblot (Abeta-SDS-PAGE/immunoblot) revealed a highly conserved Abeta peptide (Abeta1-37, 1-38, 1-39, 1-40, 1-42) pattern in CSF. We asked whether the variation might be useful to further elucidate the overlap between or distinctions among neurodegenerative diseases in Abeta-processing. We used the Abeta-SDS-PAGE/immunoblot to investigate CSF for disease-specific Abeta peptide patterns. CSF samples from 96 patients with mainly clinically diagnosed Alzheimer's disease (n = 15), progressive supranuclear palsy (n = 20), corticobasal degeneration (n = 12), Parkinson's disease (n = 11), multiple systems atrophy (n = 18), and dementia with Lewy-bodies (n = 20) were analysed as well a comparison group (n = 19). The Abeta peptide patterns varied between tauopathies and synucleinopathies and between all diseases and the comparison group, possibly due to the influence of tau and alpha-synuclein on Abeta-processing.
AuthorsB Mollenhauer, M Bibl, H Esselmann, P Steinacker, C Trenkwalder, J Wiltfang, M Otto
JournalJournal of neural transmission (Vienna, Austria : 1996) (J Neural Transm (Vienna)) Vol. 114 Issue 7 Pg. 919-27 (Jul 2007) ISSN: 1435-1463 [Electronic] Austria
PMID17318305 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Amyloid beta-Peptides
  • alpha-Synuclein
  • tau Proteins
Topics
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease (cerebrospinal fluid, etiology, pathology)
  • Amyloid beta-Peptides (biosynthesis, cerebrospinal fluid, metabolism)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple System Atrophy (cerebrospinal fluid, etiology, pathology)
  • Protein Processing, Post-Translational
  • Tauopathies (cerebrospinal fluid, etiology, pathology)
  • alpha-Synuclein (cerebrospinal fluid, physiology)
  • tau Proteins (cerebrospinal fluid, physiology)

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