| Abstract | Certain autoantibodies are characteristic of autoimmune disease manifestations and contribute to organ pathology. The presence of high-titer antibodies to U1-RNP are associated with mixed connective tissue disease, although these antibodies may also be present in systemic lupus erythematosus and systemic sclerosis. However, the role of antibodies to U1-RNP in the pathogenesis of connective tissue disease remains unclear. Data from recent experimental studies promote the hypothesis that U1-RNP antibodies participate in both innate and adaptive immune responses, implicating them in the pathogenesis of connective tissue disease. |
| Authors | Michael P Keith, Chantal Moratz, George C Tsokos
(Affiliation: Division of Rheumatology, Walter Reed Army Medical Center, Washington, DC, USA. mpkeith at bethesda.med.navy.mil)
|
| Journal | Autoimmunity reviews
(Autoimmun Rev)
Vol. 6
Issue 4
Pg. 232-6
(Mar 2007)
ISSN: 1568-9972 Netherlands |
| PMID | 17317614
(Publication Type: Journal Article, Review)
|
| Chemical References |
- Antibodies, Antinuclear
- Ribonucleoprotein, U1 Small Nuclear
- Toll-Like Receptors
|
| Topics |
- Animals
- Antibodies, Antinuclear
(immunology)
- Connective Tissue Diseases
(immunology)
- Humans
- Ribonucleoprotein, U1 Small Nuclear
(immunology)
- Toll-Like Receptors
(immunology)
|
