Overexpression of serine-threonine receptor kinase-associated protein in colorectal cancers.

Abstract

Transforming growth factor-beta (TGF-beta) regulates many cellular processes, including cellular proliferation and differentiation. Disruption of the TGF-beta signaling pathway can lead to cancer. Serine-threonine receptor kinase-associated protein (STRAP), an inhibitor of TGF-beta signaling, is an important regulator of cell proliferation. Here, in order to investigate the roles of STRAP in colorectal carcinogenesis, the expression of the STRAP protein was investigated in 59 colonic adenomas and 123 colorectal cancers by immunohistochemistry. Upregulation of STRAP protein was observed in 30 (50.8%) of 59 adenomas and 87 (70.7%) of 123 cancers, respectively. Statistically, overexpression of STRAP protein was not associated with clinicopathological parameters and 5 year survival (P > 0.05). Interestingly, significant association was observed between STRAP and Ki-67 positivity (P < 0.05), suggesting that STRAP contributes to an increased proliferate potential of tumor cells. These results indicate that upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers.

• Authors: Chang Jae Kim, Byung Jun Choi, Jae Hwi Song, Yong Kyu Park, Yong Gu Cho, Suk Woo Nam, Nam Jin Yoo, Jung Young Lee, Won Sang Park
• Journal: Pathology international (Pathol Int) Vol. 57 Issue 4 Pg. 178-82 (Apr 2007) ISSN: 1320-5463 [Print] Australia
• PMID: 17316412 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ki-67 Antigen
• Neoplasm Proteins
• RNA-Binding Proteins
• STRAP protein, human

Topics

• Adenoma (metabolism, pathology)
• Cell Proliferation
• Colorectal Neoplasms (metabolism, pathology)
• Disease Progression
• Gene Expression Regulation, Neoplastic
• Humans
• Ki-67 Antigen (genetics, metabolism)
• Neoplasm Proteins (genetics, metabolism)
• RNA-Binding Proteins
• Up-Regulation