HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Synthesis of novel L-N-MCd4T as a potent anti-HIV agent.

Abstract
L-N-MCd4T (1) has been synthesized as a potent anti-HIV agent starting from (R)-epichlorohydrin using tandem alkylation, chemoselective reduction of ester in the presence of lactone functional group, RCM reaction and Mitsunobu reaction as key steps and was found to be a very potent anti-HIV-1 (EC50 = 6.76 microg mL(-1)) agent without cytotoxicity up to 100 microg mL(-1), indicating that the anti-HIV-1 activity found is similar to that of ddI (EC50 = 4.95 microg mL(-1)), which is used clinically for the treatment of AIDS patients.
AuthorsAh-Young Park, Hyung Ryong Moon, Kyung Ran Kim, Moon Woo Chun, Lak Shin Jeong
JournalOrganic & biomolecular chemistry (Org Biomol Chem) Vol. 4 Issue 22 Pg. 4065-7 (Nov 21 2006) ISSN: 1477-0520 [Print] England
PMID17312958 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 1-(5-(hydroxymethyl)bicyclo(3.1.0)hex-3-en-2-yl)-5-methyl-1,3-dihydropyrimidine-2,4-dione
  • Anti-HIV Agents
  • Bridged Bicyclo Compounds
  • Thymidine
Topics
  • Anti-HIV Agents (chemical synthesis, chemistry, pharmacology)
  • Bridged Bicyclo Compounds (chemical synthesis, chemistry, pharmacology)
  • HIV (drug effects)
  • Humans
  • Lymphocytes (drug effects)
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Stereoisomerism
  • Thymidine (analogs & derivatives, chemical synthesis, chemistry, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: