Dietary isothiocyanate iberin inhibits growth and induces apoptosis in human glioblastoma cells.

Abstract

In this study, we evaluated the antiproliferative and proapoptotic effects of the isothiocyanate iberin, a bioactive agent in Brassicaceae species, in human glioblastoma cells. The human glioblastoma cell cultures were treated with different concentrations of iberin and tested for growth inhibition, cytotoxicity, induction of apoptosis, and activation of caspases. Iberin inhibited growth of tumor cells in cell proliferation assays, enhanced cytotoxicity, and induced apoptosis by activation of caspase-3 and caspase-9. Findings from this study could provide a basis for potential usefulness of the diet-derived isothiocyanate iberin as a promising therapeutic micronutrient in the prevention/intervention of brain tumors.

• Authors: Unmesh Jadhav, Ravesanker Ezhilarasan, Steven F Vaughn, Mark A Berhow, Sanjeeva Mohanam
• Journal: Journal of pharmacological sciences (J Pharmacol Sci) Vol. 103 Issue 2 Pg. 247-51 (Feb 2007) ISSN: 1347-8613 [Print] Japan
• PMID: 17310076 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Caspase Inhibitors
• Isothiocyanates
• iberin
• Caspases

Topics

• Antineoplastic Agents, Phytogenic
• Apoptosis (drug effects)
• Brassica (chemistry)
• Caspase Inhibitors
• Caspases (metabolism)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Diet
• Enzyme Activation (drug effects)
• Glioblastoma (drug therapy, pathology)
• Humans
• Isothiocyanates (pharmacology)