Abstract | BACKGROUND: METHODS: RESULTS: After 4 weeks of hyperglycemia one marker of mitochondrial function, NADH oxidase activity, was decreased to 50% of control animals. MRI studies of diabetic mice at 4 weeks demonstrated significant deficits in myocardial morphology and functionality including: a decreased left ventricular (LV) wall thickness, an increased LV end-systolic diameter and volume, a diminished LV ejection fraction and cardiac output, a decreased LV circumferential shortening, and decreased LV peak ejection and filling rates. M-mode echocardiographic and Doppler flow studies of diabetic mice at 4 weeks showed a decreased wall thickening and increased E/A ratio, supporting both systolic and diastolic dysfunction. CONCLUSION: Our study demonstrates that MRI interrogation can identify the onset of diabetic cardiomyopathy in mice with its impaired functional capacity and altered morphology. The MRI technique will lend itself to repetitive study of early changes in cardiac function in small animal models of diabetic cardiomyopathy.
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Authors | Xichun Yu, Yasvir A Tesiram, Rheal A Towner, Andrew Abbott, Eugene Patterson, Shijun Huang, Marion W Garrett, Suresh Chandrasekaran, Satoshi Matsuzaki, Luke I Szweda, Brian E Gordon, David C Kem |
Journal | Cardiovascular diabetology
(Cardiovasc Diabetol)
Vol. 6
Pg. 6
(Feb 19 2007)
ISSN: 1475-2840 [Electronic] England |
PMID | 17309798
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Multienzyme Complexes
- Streptozocin
- NADH oxidase
- NADH, NADPH Oxidoreductases
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Topics |
- Animals
- Blood Glucose
(metabolism)
- Body Weight
- Cardiomyopathies
(diagnosis, etiology)
- Diabetes Mellitus, Experimental
(physiopathology)
- Diabetic Angiopathies
(diagnosis, physiopathology)
- Female
- Magnetic Resonance Imaging
- Mice
- Mice, Inbred C57BL
- Mitochondria, Heart
(enzymology)
- Multienzyme Complexes
(metabolism)
- NADH, NADPH Oxidoreductases
(metabolism)
- Streptozocin
- Ventricular Dysfunction, Left
(etiology)
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