Transient gestational diabetes insipidus diagnosed in successive pregnancies: review of pathophysiology, diagnosis, treatment, and management of delivery.

Abstract

Gestational diabetes insipidus (GDI) is a rare disorder characterised by polyuria, polydypsia, and excessive thirst usually manifesting in the third trimester of pregnancy. The etiology is thought to depend on excessive vasopressinase activity, a placental enzyme that degrades arginine-vasopressin (AVP), but not 1-deamino-8-D: -arginine vasopressin (dDAVP), which is a synthetic form. This is a transient syndrome and may be associated with acute fatty liver of pregnancy and preeclampsia. The use of dDAVP in symptomatic cases has been proven as a safe method for both the mother and the fetus during the pregnancy. We report a case of recurrent gestational diabetes insipidus in successive pregnancies, which responded to dDAVP and subsided after delivery.

• Authors: Ibrahim Kalelioglu, Ayse Kubat Uzum, Alkan Yildirim, Tulay Ozkan, Funda Gungor, Recep Has
• Journal: Pituitary (Pituitary) Vol. 10 Issue 1 Pg. 87-93 ( 2007) ISSN: 1386-341X [Print] United States
• PMID: 17308961 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Deamino Arginine Vasopressin

Topics

• Adult
• Cesarean Section, Repeat
• Deamino Arginine Vasopressin (therapeutic use)
• Diabetes Insipidus (diagnosis, drug therapy, physiopathology)
• Diabetes, Gestational (diagnosis, drug therapy, physiopathology)
• Female
• Humans
• Magnetic Resonance Imaging
• Pregnancy