Quantitative evaluation of 2-deoxy-2[F-18]fluoro-D-glucose-positron emission tomography imaging on the woodchuck model of hepatocellular carcinoma with histological correlation.

Abstract

PURPOSE:

The Eastern woodchuck (Marmota monax) is considered as a naturally occurring animal model of hepatocellular carcinoma (HCC). The performance of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) for imaging HCC on the woodchuck using Positron emission tomography (PET) was investigated in this study.

PROCEDURES:

Dynamic FDG-PET scans were performed on five woodchucks with HCC and one healthy woodchuck before removal and processing of the liver tissues for histology. The parameters of a two-tissue compartment model with dual input were estimated using weighted least squares (WLS).

RESULTS:

Ten HCCs were confirmed histologically. Six HCCs had a tumor-to-liver standardized uptake value (SUV) ratio < or =1.15, a k (4) / k (3) ratio similar to that in hepatic tissues and were well-differentiated. Four HCCs had a tumor-to-liver SUV ratio >1.15, a lower k (4) / k (3) ratio than the hepatic tissues and were moderately differentiated.

CONCLUSIONS:

Increased FDG uptake was observed in HCCs that were the least differentiated and correlated with a lower k (4) / k (3) ratio.

• Authors: Nicolas Salem, Gregory T MacLennan, Yu Kuang, Paul W Anderson, Steve J Schomisch, Ilia A Tochkov, Bud C Tennant, Zhenghong Lee
• Journal: Molecular imaging and biology (Mol Imaging Biol) 2007 May-Jun Vol. 9 Issue 3 Pg. 135-43 ISSN: 1536-1632 [Print] United States
• PMID: 17308952 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Fluorine Radioisotopes
• Radiopharmaceuticals
• Fluorodeoxyglucose F18

Topics

• Animals
• Fluorine Radioisotopes
• Fluorodeoxyglucose F18
• Hepatitis B Virus, Woodchuck (pathogenicity)
• Liver Neoplasms, Experimental (diagnostic imaging, pathology, virology)
• Marmota
• Models, Statistical
• Positron-Emission Tomography (methods, statistics & numerical data)
• Radiopharmaceuticals