Transient neonatal hypothyroidism is associated with elevated serum anti-thyroglobulin antibody levels in newborns and their mothers.

Abstract

Transient congenital hypothyroidism (TCH) was detected in 6 of 35,067 newborns (1:5845 births) screened in Iran. Antithyroglobulin antibodies positivity was present in 4 of 6 (66.7%) of those with TCH and in 6 of 106 (5.7%) of those with "transient hyperthyrotropinemia and normal" diagnoses (P = .0005), but positivity was similar in newborns with transient hyperthyrotropinemia versus normal neonates (P = .397).

• Authors: Arash Ordookhani, Parvin Mirmiran, Paul G Walfish, Fereidoun Azizi
• Journal: The Journal of pediatrics (J Pediatr) Vol. 150 Issue 3 Pg. 315-7, 317.e2 (Mar 2007) ISSN: 1097-6833 [Electronic] United States
• PMID: 17307555 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• Receptors, Thyrotropin
• anti-thyroglobulin

Topics

• Adult
• Autoantibodies (blood)
• Cohort Studies
• Congenital Hypothyroidism (diagnosis, epidemiology)
• Female
• Follow-Up Studies
• Humans
• Incidence
• Infant, Newborn
• Male
• Neonatal Screening
• Pregnancy
• Pregnancy Complications (diagnosis, immunology)
• Probability
• Receptors, Thyrotropin (blood)
• Risk Assessment
• Statistics, Nonparametric
• Thyroid Function Tests