HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Granulosa cell tumors of the ovary: the clinical value of serum inhibin A and B levels in a large single center cohort.

AbstractOBJECTIVES:
In patients with a granulosa cell tumor of the ovary, the value of serum inhibin A and B concentrations for the assessment of disease status was investigated.
METHODS:
In 30 consecutive patients with a stage I-III granulosa cell tumor, inhibin A and B concentrations were measured in pre- and post-treatment serum samples. Clinical data concerning diagnosis, treatment and follow-up of these patients were related to serum inhibin A and B concentrations. Serum samples from 41 premenopausal females with cervical dysplasia served as controls.
RESULTS:
In 30 patients, 13 (43%) recurrences were observed during a median follow-up of 10 years (range 1-31 years). Serum inhibin A and B concentrations were elevated in respectively 67% and 89% of the patients at diagnosis, and in 58% and 85% at recurrence. Inhibin A and B concentrations were normal in all controls. Sensitivity of inhibin A testing for the diagnosis of granulosa cell tumor was 67% with a specificity of 100%, compared to 89% and 100% respectively for inhibin B (ns). Elevations in serum inhibin B concentrations predated recurrences by a median of 11 months. None of the patients in remission showed increased concentrations of inhibin A and B.
CONCLUSION:
Inhibin B seems to be the predominant form of inhibin secreted by granulosa cell tumors and appears to reflect disease status more accurately than inhibin A. Measurement of serum inhibin B concentrations may be preferred for the follow-up of granulosa cell tumors.
AuthorsC H Mom, M J A Engelen, P H B Willemse, J A Gietema, K A ten Hoor, E G E de Vries, A G J van der Zee
JournalGynecologic oncology (Gynecol Oncol) Vol. 105 Issue 2 Pg. 365-72 (May 2007) ISSN: 0090-8258 [Print] United States
PMID17306349 (Publication Type: Journal Article)
Chemical References
  • inhibin A
  • inhibin B
  • Inhibins
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Chemotherapy, Adjuvant
  • Child
  • Child, Preschool
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Granulosa Cell Tumor (blood, therapy)
  • Humans
  • Inhibins (blood)
  • Intraoperative Period
  • Middle Aged
  • Ovarian Neoplasms (blood, therapy)
  • Radiotherapy, Adjuvant
  • Uterine Cervical Dysplasia (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: