Abstract | OBJECTIVES: METHODS: In 30 consecutive patients with a stage I-III granulosa cell tumor, inhibin A and B concentrations were measured in pre- and post-treatment serum samples. Clinical data concerning diagnosis, treatment and follow-up of these patients were related to serum inhibin A and B concentrations. Serum samples from 41 premenopausal females with cervical dysplasia served as controls. RESULTS: In 30 patients, 13 (43%) recurrences were observed during a median follow-up of 10 years (range 1-31 years). Serum inhibin A and B concentrations were elevated in respectively 67% and 89% of the patients at diagnosis, and in 58% and 85% at recurrence. Inhibin A and B concentrations were normal in all controls. Sensitivity of inhibin A testing for the diagnosis of granulosa cell tumor was 67% with a specificity of 100%, compared to 89% and 100% respectively for inhibin B (ns). Elevations in serum inhibin B concentrations predated recurrences by a median of 11 months. None of the patients in remission showed increased concentrations of inhibin A and B. CONCLUSION:
|
Authors | C H Mom, M J A Engelen, P H B Willemse, J A Gietema, K A ten Hoor, E G E de Vries, A G J van der Zee |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 105
Issue 2
Pg. 365-72
(May 2007)
ISSN: 0090-8258 [Print] United States |
PMID | 17306349
(Publication Type: Journal Article)
|
Chemical References |
- inhibin A
- inhibin B
- Inhibins
|
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Chemotherapy, Adjuvant
- Child
- Child, Preschool
- Cohort Studies
- Female
- Follow-Up Studies
- Granulosa Cell Tumor
(blood, therapy)
- Humans
- Inhibins
(blood)
- Intraoperative Period
- Middle Aged
- Ovarian Neoplasms
(blood, therapy)
- Radiotherapy, Adjuvant
- Uterine Cervical Dysplasia
(blood)
|