Superior cervical ganglionectomy in monkeys: surgical technique.

Abstract

Seven cynomolgus monkeys underwent a histologically confirmed left superior cervical ganglionectomy (SCGx). Unilateral ocular sympathetic denervation persisting for at least 2 yr was confirmed by ipsilateral ptosis, miosis, supersensitivity of pupillary dilation to topical phenylephrine, and profound pupillary hyporesponsiveness to topical hydroxyamphetamine. Intraocular pressure 8-9 and 23-27 months postoperatively were identical in the denervated and contralateral control eyes. This model should facilitate studies of aqueous humor physiology and pharmacology.

• Authors: J C Robinson, P L Kaufman
• Journal: Investigative ophthalmology & visual science (Invest Ophthalmol Vis Sci) Vol. 33 Issue 1 Pg. 247-51 (Jan 1992) ISSN: 0146-0404 [Print] United States
• PMID: 1730545 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Phenylephrine
• p-Hydroxyamphetamine

Topics

• Administration, Topical
• Animals
• Female
• Ganglia, Sympathetic (pathology, surgery)
• Ganglionectomy (methods)
• Intraocular Pressure
• Macaca fascicularis
• Phenylephrine (pharmacology)
• Pupil (drug effects)
• p-Hydroxyamphetamine (pharmacology)