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N6-isopentenyladenosine: a potential therapeutic agent for a variety of epithelial cancers.

Abstract
Isopentenyladenosine (i(6)A) is a product of isopentenyltransferases and, in mammals, occurs either bound to tRNA or as a free nucleoside. Sporadic reports have suggested an anticancer effect of i(6)A, mostly on leukemia cells. The present analysis of 9 human epithelial cancer cell lines derived from different types of malignant tissue revealed complete suppression of clonogenic activity in 8 of the lines after exposure to i(6)A at a concentration of 10 muM. Mechanistic studies showed that i(6)A tumor suppressor activity is associated with inhibition of cell proliferation, a block in DNA synthesis and morphological changes. These results point to i(6)A and to its possible derivatives as a new potential class of wide-spectrum anticancer agents.
AuthorsMonica Spinola, Francesca Colombo, F Stefania Falvella, Tommaso A Dragani
JournalInternational journal of cancer (Int J Cancer) Vol. 120 Issue 12 Pg. 2744-8 (Jun 15 2007) ISSN: 0020-7136 [Print] United States
PMID17304507 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • DNA, Neoplasm
  • Isopentenyladenosine
  • Geranyltranstransferase
  • Caspase 3
  • Caspase 7
Topics
  • Antineoplastic Agents (pharmacology, therapeutic use)
  • Apoptosis (drug effects)
  • Blotting, Western
  • Caspase 3 (metabolism)
  • Caspase 7 (metabolism)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Cell Shape (drug effects)
  • DNA, Neoplasm (biosynthesis)
  • Dose-Response Relationship, Drug
  • Epithelial Cells (drug effects, metabolism, pathology)
  • Geranyltranstransferase (metabolism)
  • HT29 Cells
  • Humans
  • Isopentenyladenosine (pharmacology, therapeutic use)
  • Neoplasms (drug therapy, metabolism, pathology)
  • Time Factors
  • Tumor Stem Cell Assay

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