Serum resistin is associated with the severity of microangiopathies in type 2 diabetes.

Abstract

Resistin, secreted from adipocytes, causes insulin resistance and diabetes in rodents. To determine the relation between serum resistin and diabetic microangiopathies in humans, we analyzed 238 Japanese T2DM subjects. Mean serum resistin was higher in subjects with either advanced retinopathy (preproliferative or proliferative) (P=0.0130), advanced nephropathy (stage III or IV) (P=0.0151), or neuropathy (P=0.0013). Simple regression analysis showed that serum resistin was positively correlated with retinopathy stage (P=0.0212), nephropathy stage (P=0.0052), and neuropathy (P=0.0013). Multiple regression analysis adjusted for age, gender, and BMI, revealed that serum resistin was correlated with retinopathy stage (P=0.0144), nephropathy stage (P=0.0111), and neuropathy (P=0.0053). Serum resistin was positively correlated with the number of advanced microangiopathies, independent of age, gender, BMI, and either the duration of T2DM (P=0.0318) or serum creatinine (P=0.0092). Therefore, serum resistin was positively correlated with the severity of microangiopathies in T2DM.

• Authors: Haruhiko Osawa, Masaaki Ochi, Kenichi Kato, Junko Yamauchi, Wataru Nishida, Yasunori Takata, Ryoichi Kawamura, Hiroshi Onuma, Tomomi Takasuka, Ikki Shimizu, Yasuhisa Fujii, Jun Ohashi, Hideichi Makino
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 355 Issue 2 Pg. 342-6 (Apr 06 2007) ISSN: 0006-291X [Print] United States
• PMID: 17303077 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Resistin

Topics

• Aged
• Diabetes Mellitus, Type 2 (blood, complications, physiopathology)
• Diabetic Angiopathies (blood, physiopathology)
• Female
• Humans
• Male
• Middle Aged
• Resistin (blood)
• Severity of Illness Index