[Experimental study on treatment of immune ulcerative colitis in mice by Changlu Enema].

Abstract

OBJECTIVE:

To observe the therapeutic effect of Chinese compound, Changlu Enema (CE), on immune ulcerative colitis (UC) in mice.

METHODS:

Mice were randomly divided into the normal group, the model group, the CE high dose (CE-H) and low dose (CE-L) group and the salicylazosulfapyridine (SASP) group. All mice, except those in the normal group, were made into UC model by colonic mucosa protein immunization. After 21 days of medication, the changes of UC activity index and body weight in mice were observed, and the condition of colonic inflammation and histomorphological changes in colonic tissue were observed also.

RESULTS:

UC activity index was lower and body weight was higher in the two CE groups than those in the model group respectively, showing significant difference (P < 0.05 or P < 0.01); pathological examination showed the pathological changes and inflammatory response in colonic tissue were relieved significantly after treatment, and the improvement in the CE-H group was better than that in the SASP group.

CONCLUSION:

TCM compound CE is markedly effective in treating UC rats.

• Authors: Yao-nan Wu, Yu-qin Xiao, Yi-bin Chen
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 27 Issue 1 Pg. 65-8 (Jan 2007) ISSN: 1003-5370 [Print] China
• PMID: 17302068 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• changlu

Topics

• Administration, Rectal
• Animals
• Colitis, Ulcerative (drug therapy, immunology)
• Colon (drug effects, pathology)
• Drugs, Chinese Herbal (administration & dosage, therapeutic use)
• Male
• Mice
• Phytotherapy
• Random Allocation
• Treatment Outcome