| Abstract | The only US licensed vaccine with established efficacy against smallpox, Dryvax, is contraindicated for HIV patients. Detectable smallpox-neutralizing antibodies are still present among US adults. This study compared vaccinia-neutralizing antibody titers between 20 HIV-infected and 20 uninfected veterans matched for age and military entry. Vaccinia-neutralizing antibodies were detected in 95% HIV-infected and 100% uninfected veterans; 40% HIV-infected and 70% uninfected adults had protective titers. Therefore, after robust vaccination, neutralizing antibodies are maintained for prolonged times despite CD4 cell depletion. |
| Authors | Virginia L Kan, Jody Manischewitz, Lisa R King, Hana Golding
(Affiliation: Infectious Diseases Section, Veterans Affairs Medical Center, Washington, DC, USA.)
|
| Journal | AIDS (London, England)
(AIDS)
Vol. 21
Issue 4
Pg. 521-4
(Feb 19 2007)
ISSN: 0269-9370 England |
| PMID | 17301573
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
|
| Chemical References |
- Antibodies, Viral
- DryVax vaccine
- Smallpox Vaccine
|
| Topics |
- Adult
- Antibodies, Viral
(blood)
- CD4 Lymphocyte Count
- Female
- HIV Infections
(immunology)
- Humans
- Male
- Middle Aged
- Pilot Projects
- Smallpox Vaccine
(immunology)
- Time Factors
- Vaccinia virus
(immunology)
- Veterans
|
