[A case of multiple lung metastases of hepatocellular carcinoma after resection of liver and tumor thrombi in the inferior vena cava responding to chemotherapy using 5-FU, mitoxantrone and CDDP].

Abstract

A 58-year-old man, who had a history of chronic type B hepatitis, was diagnosed as hepatocellular carcinoma with tumor thrombi in the inferior vena cava. He underwent resection of central bisegments and tumor thrombi, while postoperative chest CT demonstrated multiple lung metastases. Following 2 courses of chemotherapy using 5-FU, mitoxantrone, and CDDP (FMP therapy), multiple lung nodules disappeared and alpha-fetoprotein returned to the normal level. FMP therapy thus proved effective for a case of distant metastases of hepatocellular carcinoma.

• Authors: Tadahiko Enoki, Kouji Kitada, Eijirou Harada, Shinji Noshima, Kimikazu Hamano
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 34 Issue 2 Pg. 229-31 (Feb 2007) ISSN: 0385-0684 [Print] Japan
• PMID: 17301533 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• alpha-Fetoproteins
• Mitoxantrone
• Cisplatin
• Fluorouracil

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Hepatocellular (secondary, surgery)
• Cisplatin (administration & dosage)
• Drug Administration Schedule
• Fluorouracil (administration & dosage)
• Humans
• Liver Neoplasms (pathology, surgery)
• Lung Neoplasms (drug therapy, secondary)
• Male
• Middle Aged
• Mitoxantrone (administration & dosage)
• Neoplastic Cells, Circulating (pathology)
• Postoperative Period
• Remission Induction
• Vena Cava, Inferior (pathology, surgery)
• alpha-Fetoproteins (analysis)