Inhibitory effect of prostaglandin oligomeric derivatives on 9,10-dimethyl-1,2-benzanthracene-induced hamster lingual carcinomas.

Abstract

The inhibitory effects of prostaglandin oligomeric derivatives OC-3186 and OC-5186 were examined in hamster lingual carcinoma induced by 9,10-dimethyl-1,2-benzanthracene (DMBA). These compounds caused a regression of 40-90% in the size of lingual carcinomas in the hamster within several days after systemic or local administration.

• Authors: S Hidaka, N Morita, S T Ohnishi, Y Oga, K Abe
• Journal: Cancer letters (Cancer Lett) Vol. 61 Issue 2 Pg. 171-6 (Jan 10 1992) ISSN: 0304-3835 [Print] Ireland
• PMID: 1730141 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Prostaglandins B
• MR 356
• OC 5186
• 9,10-Dimethyl-1,2-benzanthracene
• Alprostadil

Topics

• 9,10-Dimethyl-1,2-benzanthracene (antagonists & inhibitors)
• Alprostadil (analogs & derivatives, pharmacology)
• Animals
• Antineoplastic Agents (pharmacology)
• Carcinoma, Squamous Cell (drug therapy, pathology)
• Cricetinae
• Mesocricetus
• Prostaglandins B (pharmacology)
• Rats
• Tongue Neoplasms (drug therapy, pathology)