Neuroprotective effects of kobophenol A against the withdrawal of tropic support, nitrosative stress, and mitochondrial damage in SH-SY5Y neuroblastoma cells.

Abstract	This study examined the neuroprotective effects of kobophenol A (kob A), oligomeric stillbene, and a resveratrol tetramer. Neuronal death induced by the withdrawal of tropic support was ameliorated by kob A. The protective effect of kob A against nitrosative/oxidative or mitochondrial damages resulted in the inhibition of the ROS, intracellular calcium ion level, and mitochondrial transmembrane potential changes on SH-SY5Y cells.
Authors	Sung Ryul Lee, Jong Hwan Kwak, Hyoung Ja Kim, Suhkneung Pyo
Journal	Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 17 Issue 7 Pg. 1879-82 (Apr 01 2007) ISSN: 0960-894X [Print] England
PMID	17300930 (Publication Type: Journal Article)
Chemical References	Ions Stilbenes kobophenol A Nitrogen Oxygen Calcium
Topics	Calcium (metabolism) Cell Line, Tumor Chemistry, Pharmaceutical (methods) Drug Design Drug Screening Assays, Antitumor Humans Ions Membrane Potentials Mitochondria (metabolism) Models, Chemical Molecular Conformation Nitrogen (chemistry) Oxygen (chemistry) Stilbenes (chemical synthesis, chemistry, pharmacology)

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