[Delta-opioid receptor activation prevents appearance of irreversible damages of cardiomyocytes and exacerbates myocardial contractility dysfunction during ischemia and reperfusion].

Abstract

It is shown that prestimulation of cardiac delta-opioid receptors (OR) by selective agonists (DPDPE and TAN-67) decreases creatine kinase levels in the coronary effluent of isolated rat heart during 45-min global ischemia and 30-min reperfusion. This effect was completely abolished by pretreatment with a delta-antagonist naltrindole or a non-selective agonist naloxone. It was found that preactivation of cardiac delta-OR exacerbates reperfusion contractility dysfunction of the heart. This effect was also eliminated by opioid receptor antagonists. It is suggested that stimulation of cardiac delta-OR prevents irreversible cardiac cell damage but exacerbates contractility dysfunction during ischemia and reperfusion in vitro.

• Authors: L N Maslov, A A Platonov, T V Lasukova, Iu B Lishmanov, P Oeltgen, H Nagase, Iu K Podoksenov, A Iu Podoksenov
• Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia (Patol Fiziol Eksp Ter) 2006 Oct-Dec Issue 4 Pg. 13-7 ISSN: 0031-2991 [Print] Russia (Federation)
• PMID: 17300082 (Publication Type: English Abstract, Journal Article)

Chemical References

• Neurotransmitter Agents
• Quinolines
• Receptors, Opioid, delta
• TAN 67
• Enkephalin, D-Penicillamine (2,5)-
• Creatine Kinase

Topics

• Animals
• Creatine Kinase (analysis)
• Enkephalin, D-Penicillamine (2,5)- (pharmacology)
• Heart (physiopathology)
• In Vitro Techniques
• Male
• Myocardial Contraction
• Myocardial Reperfusion Injury (metabolism, pathology, prevention & control)
• Myocytes, Cardiac (pathology)
• Neurotransmitter Agents (pharmacology)
• Quinolines (pharmacology)
• Rats
• Rats, Wistar
• Receptors, Opioid, delta (agonists)