Chiral Diphenylprolinol TES ether promoted conjugate addition-aldol-dehydration reactions between alpha,beta-unsaturated aldehydes and 2-N-protected amino benzaldehydes.

Abstract	A conjugate addition-aldol-dehydration reaction of alpha,beta-unsaturated aldehydes with 2-N-protected amino benzaldehydes has been developed. The process is promoted by (S)-diphenylprolinol TES ether to afford synthetically useful 1,2-dihydroquinolines in high enantioselectivities with good yields. [reaction: see text]
Authors	Hao Li, Jian Wang, Hexin Xie, Liansuo Zu, Wei Jiang, Eileen N Duesler, Wei Wang
Journal	Organic letters (Org Lett) Vol. 9 Issue 6 Pg. 965-8 (Mar 15 2007) ISSN: 1523-7060 [Print] United States
PMID	17298072 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References	Aldehydes Amines Benzaldehydes Pyrrolidines Quinolines Tromethamine Ether prolinol TES
Topics	Aldehydes (chemistry) Amines (chemistry) Benzaldehydes (chemistry) Dehydration Ether (analogs & derivatives) Models, Chemical Pyrrolidines (chemistry) Quinolines (chemical synthesis) Stereoisomerism Tromethamine (analogs & derivatives, chemistry)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!