Abstract |
Few studies have compared ivermectin directly with topical agents in developing countries. We compared the effectiveness of oral ivermectin (200 microg/kg) with topical 25% benzyl benzoate and monosulfiram soap in 210 subjects of age 5 to 65 years with scabies. Subjects with persistent lesions after 2 weeks received a second course of treatment. All lesions had resolved after 2 weeks in 77 of 98 (79%) subjects treated with ivermectin and in 60 of 102 (59%) subjects treated topically (P = 0.003). The improvement in severity score was greater in the ivermectin group than in the topical treatment group (P < 0.001). The overall cure rate after 4 weeks was 95% in the ivermectin group and 86% in the topical treatment group (P = 0.04). Compared with topical benzyl benzoate and monosulfiram in the treatment of scabies, ivermectin was at least as effective and led to more rapid improvement.
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Authors | Halima M Sule, Tom D Thacher |
Journal | The American journal of tropical medicine and hygiene
(Am J Trop Med Hyg)
Vol. 76
Issue 2
Pg. 392-5
(Feb 2007)
ISSN: 0002-9637 [Print] United States |
PMID | 17297053
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzoates
- Insecticides
- monosulfiram
- Ivermectin
- benzyl benzoate
- Disulfiram
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Topics |
- Administration, Oral
- Administration, Topical
- Adolescent
- Adult
- Aged
- Animals
- Benzoates
(administration & dosage)
- Child
- Child, Preschool
- Disulfiram
(administration & dosage, analogs & derivatives)
- Female
- Humans
- Insecticides
(administration & dosage)
- Ivermectin
(administration & dosage)
- Male
- Middle Aged
- Nigeria
- Regression Analysis
- Sarcoptes scabiei
(growth & development)
- Scabies
(drug therapy)
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