Abstract | BACKGROUND: OBJECTIVES: To describe the safety and efficacy of CroFab in pediatric crotaline envenomations. METHODS: Using admission and billing records, the authors identified all children 13 years of age and younger treated with CroFab at a pediatric hospital between October 2000 and September 2005. Charts were reviewed by two trained, blinded extractors. Data regarding age, signs of envenomation, laboratory values, total antivenom vials used, total vials used to gain control, transfused blood products, signs of acute allergy to antivenom, and any surgical procedures were abstracted. Data were analyzed using descriptive statistics. RESULTS: Twenty-four patients were identified, and their mean age was 7.3 (range, 1.9-13) years. At presentation, all had swelling, 14 (58%) had a prothrombin time >13 seconds, two (8.3%) had a fibrinogen level <150 mg/dL, and three (12.5%) had platelet counts <150,000/mL. The mean number of total antivenom vials used was 12.3 (range, 4-24). Five patients had resolution of swelling, but platelet counts continued to fall despite antivenom treatment. No patient required blood products, debridement of skin, or fasciotomy. There was only one (4.2%) possible acute allergy to CroFab, and there were no deaths. CONCLUSIONS:
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Authors | Anthony F Pizon, Bradley D Riley, Frank LoVecchio, Ruqayya Gill |
Journal | Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
(Acad Emerg Med)
Vol. 14
Issue 4
Pg. 373-6
(Apr 2007)
ISSN: 1553-2712 [Electronic] United States |
PMID | 17296804
(Publication Type: Journal Article)
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Chemical References |
- Antivenins
- Crotalidae Polyvalent immune Fab
- Immunoglobulin Fab Fragments
- Immunoglobulin Fragments
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Topics |
- Adolescent
- Antivenins
(therapeutic use)
- Child
- Child, Preschool
- Female
- Hospitals, Pediatric
- Humans
- Immunoglobulin Fab Fragments
- Immunoglobulin Fragments
(therapeutic use)
- Infant
- Male
- Retrospective Studies
- Snake Bites
(therapy)
- Treatment Outcome
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