Petasiphenone, a phenol isolated from Cimicifuga racemosa, in vitro inhibits proliferation of the human prostate cancer cell line LNCaP.

Abstract

Extracts of Cimicifuga racemosa (L.) Nutt. (syn.: Actaea racemosa L.) (CR) inhibit the proliferation of the human prostate cancer cell line LNCaP. Recently, the phenylpropanoid ester 3,4-dihydroxyphenacyl caffeate (petasiphenone, 1) was isolated from CR. This substance is a structural homologue to petasiphenol ([3-(3,4-dihydroxyphenyl)-2-oxopropyl caffeate]), a compound produced by Petasites japonicus Sieb. & Zucc. which inhibits the growth of various human leukemia cell lines. Because of the structural similarity, we examined whether 1 affects the proliferation of LNCaP cells and the secretion of prostate-specific antigen (PSA). Under basal conditions as well as under co-incubation with 10 nM estradiol [E2 or 1 nM dihydrotestosterone (DHT)], 1 dose-dependently inhibited proliferation of LNCaP cells while PSA release per cell was not altered. We report for the first time that a defined compound isolated from CR inhibits the growth of the human prostate cancer cells LNCaP.

• Authors: Hubertus Jarry, Stefan Stromeier, Wolfgang Wuttke, Adolf Nahrstedt
• Journal: Planta medica (Planta Med) Vol. 73 Issue 2 Pg. 184-7 (Feb 2007) ISSN: 0032-0943 [Print] Germany
• PMID: 17295185 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Caffeic Acids
• Phenols
• Plant Extracts
• 3,4-dihydroxyphenacyl caffeate phenylpropanoid ester

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Caffeic Acids (chemistry, isolation & purification, pharmacology)
• Carcinoma (drug therapy, pathology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Cimicifuga (chemistry)
• Humans
• Male
• Phenols (chemistry, isolation & purification, pharmacology)
• Plant Extracts (chemistry)
• Prostatic Neoplasms (drug therapy, pathology)