Efficacy of alpha-lipoic acid against diabetic cataract in rat.

Abstract

PURPOSE:

alpha-Lipoic acid (LA) is well known as a powerful antioxidant. The efficacy of dihydrolipoate-LA for oral administration against streptozotocin (STZ)-induced diabetic cataract in rat was investigated.

METHODS:

Rats were divided into three groups, control, diabetes mellitus (DM), and DM treated with LA (DM+LA). Diabetes was induced by intravenous injection of 50 mg/kg STZ. DM+LA rats were fed 30 mg/rat per day LA in their diet. Lens changes were assessed using Scheimpflug images (EAS-1000) and by measuring light-scattering intensity.

RESULTS:

Increase in lens light scattering was less (P < 0.05) in DM+LA rats than in DM rats 5 weeks after induction of diabetes. DM rats had the highest and control rats the lowest blood glucose levels at every measurement point up to 111 days (P < 0.05).

CONCLUSION:

LA treatment delayed development and progression of cataract in rats with streptozotocin-induced diabetes.

• Authors: Masami Kojima, Li Sun, Ikuho Hata, Yasuo Sakamoto, Hiroshi Sasaki, Kazuyuki Sasaki
• Journal: Japanese journal of ophthalmology (Jpn J Ophthalmol) 2007 Jan-Feb Vol. 51 Issue 1 Pg. 10-3 ISSN: 0021-5155 [Print] Japan
• PMID: 17295134 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: (c) Japanese Ophthalmological Society 2007.

Chemical References

• Antioxidants
• Blood Glucose
• Thioctic Acid
• dihydrolipoic acid

Topics

• Administration, Oral
• Animals
• Antioxidants (therapeutic use)
• Blood Glucose (analysis)
• Cataract (drug therapy, physiopathology)
• Diabetes Mellitus, Experimental (drug therapy, physiopathology)
• Disease Progression
• Drug Therapy, Combination
• Female
• Lens, Crystalline (physiopathology)
• Light
• Rats
• Rats, Inbred BN
• Scattering, Radiation
• Thioctic Acid (analogs & derivatives, therapeutic use)
• Treatment Outcome