Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: Despite potential increases in serum calcium and phosphorus due to activation of vitamin D receptors in the gut, vitamin D administration has been associated with a survival benefit in recent studies. While the mechanism for this possible benefit is unknown, vitamin D administration may have effects beyond its traditional role in mineral metabolism, mediated through the activation of vitamin D receptors distributed in a variety of tissues. SUMMARY: Data currently suggests that the administration of vitamin D confers a survival benefit to patients on dialysis. There is no clear mechanism, however, to explain this association. Further research is needed to clarify the expanding role of vitamin D receptor activation, particularly in vascular calcification, and the effects of the different forms of vitamin D.
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Authors | Steven Cheng, Daniel Coyne |
Journal | Current opinion in nephrology and hypertension
(Curr Opin Nephrol Hypertens)
Vol. 16
Issue 2
Pg. 77-82
(Mar 2007)
ISSN: 1062-4821 [Print] England |
PMID | 17293681
(Publication Type: Journal Article, Review)
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Chemical References |
- Parathyroid Hormone
- Receptors, Calcitriol
- Vitamin D
- Phosphorus
- Calcium
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Topics |
- Calcium
(metabolism)
- Humans
- Kidney Failure, Chronic
(complications, metabolism)
- Parathyroid Hormone
(metabolism)
- Phosphorus
(metabolism)
- Receptors, Calcitriol
(metabolism)
- Vitamin D
(administration & dosage, physiology)
- Vitamin D Deficiency
(drug therapy, etiology)
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