| Abstract | Primary percutaneous coronary intervention (PCI) with stent implantation is the preferred method of reperfusion for ST-elevation acute myocardial infarction. Concern remains over the use of drug-eluting stents in the acute ST-elevation myocardial infarction setting, with limited published reports on their use for this application. We studied 64 consecutive patients presenting with an acute ST-elevation myocardial infarction who underwent mechanical reperfusion with implantation of a drug-eluting stent. Both sirolimus- and paclitaxel-eluting stents were used. Primary outcome was the occurrence of major adverse cardiac events, defined as death, nonfatal reinfarction or clinically driven target vessel revascularization. Post-procedural success was achieved in 63 patients (98%). In-hospital mortality was 1.6%. During a median follow-up of 234 days, there were no cases of stent thrombosis, reinfarction or reintervention. These findings conducted in a 'real world' practice setting in the United States demonstrate that drug-eluting stent implantation for acute ST-elevation myocardial infarction is safe and effective, with a low rate of major adverse cardiac events during mid-term follow-up. |
| Authors | Gian M Novaro, Aparna Cherla, Kenneth R Fromkin, Howard S Bush
(Affiliation: Department of Cardiology, Cleveland Clinic Florida, Weston, FL 33331, USA. novarog at ccf.org)
|
| Journal | Cardiovascular revascularization medicine : including molecular interventions
(Cardiovasc Revasc Med)
2007 Jan-Mar
Vol. 8
Issue 1
Pg. 5-8
ISSN: 1553-8389 United States |
| PMID | 17293262
(Publication Type: Journal Article)
|
| Chemical References |
- Antineoplastic Agents, Phytogenic
- Drug Implants
- Immunosuppressive Agents
- Paclitaxel
- Sirolimus
|
| Topics |
- Acute Disease
- Aged
- Aged, 80 and over
- Angioplasty, Transluminal, Percutaneous Coronary
- Antineoplastic Agents, Phytogenic
(administration & dosage)
- Drug Delivery Systems
- Drug Implants
- Electrocardiography
- Female
- Follow-Up Studies
- Humans
- Immunosuppressive Agents
(administration & dosage)
- Male
- Middle Aged
- Myocardial Infarction
(drug therapy, surgery, therapy)
- Paclitaxel
(administration & dosage)
- Sirolimus
(administration & dosage)
- Stents
- Treatment Outcome
|
