[Pregnancy outcomes following pulsatile GnRH treatment: results of a large multicenter retrospective study].

Abstract

OBJECTIVES:

The aim of the present study was to evaluate the efficacy of pulsatile GnRH treatment in a large French cohort of patients with hypogonadotropic hypogonadism.

METHODS:

A retrospective study involving all women treated with pulsatile GnRH, over a 3-year period, in 24 French centers. Pregnancy rate and pregnancy outcome were the criteria for evaluation.

RESULTS:

The study included 248 women who received a total of 829 treatment cycles. The treatment routes of administration were subcutaneous (56.1% of the patients), intravenous (31.1%), or both (12.7%). The pregnancy rate per treatment cycle was 25%, while the mean number of cycles needed to obtain a pregnancy was 2.8+/-1.7. The miscarriage rate was 8.2% and the multiple pregnancy rates 8.8%. The mean delivery term was 38.4+/-2.4 weeks and the mean birth weight was 3009+/-561 g. No severe ovarian hyperstimulation was recorded. Ovarian cysts occurred in 2.3% of the treatment cycles, local allergies in 1.7%.

CONCLUSION:

Our study has shown that pulsatile GnRH treatment was well tolerated, without severe hyperstimulation. It induced a good pregnancy rate with favorable pregnancy outcomes.

• Authors: S Christin-Maitre, M de Crécy, Groupe Français des pompes à GnRH
• Journal: Journal de gynecologie, obstetrique et biologie de la reproduction (J Gynecol Obstet Biol Reprod (Paris)) Vol. 36 Issue 1 Pg. 8-12 (Feb 2007) ISSN: 0368-2315 [Print] France
• Vernacular Title: Grossesses obtenues par administration pulsatile de GnRH: résultats d'une large étude rétrospective multicentrique.
• PMID: 17293247 (Publication Type: English Abstract, Journal Article, Multicenter Study)

Chemical References

• Fertility Agents, Female
• Gonadotropin-Releasing Hormone

Topics

• Administration, Cutaneous
• Adult
• Cohort Studies
• Female
• Fertility Agents, Female (administration & dosage)
• Gonadotropin-Releasing Hormone (administration & dosage)
• Humans
• Hypogonadism (complications)
• Injections, Intravenous
• Pregnancy
• Pregnancy Outcome
• Pregnancy Rate
• Retrospective Studies