| Abstract | BACKGROUND: Primary vaginal clear cell adenocarcinoma (CCA) is a rare gynecological malignancy occurring predominantly in young females with a history of diethylstilbestrol exposure in utero. Vaginal CCA commonly metastasizes to the lungs and the supraclavicular lymph nodes; however we present a rare case of diethylstilbestrol-induced vaginal CCA with cerebral metastases. CASE DESCRIPTION: A 43-year-old woman with prenatal diethylstilbestrol exposure and history of vaginal CCA treatment 8 years prior to current presentation noted new onset headache and dizziness. MRI showed an enhancing mass in the right frontal lobe. Histopathology was consistent with CCA. CONCLUSIONS: This case report highlights the necessity of close extended follow-up in patients with a history of vaginal CCA and demonstrates the potential for spread of primary vaginal CCA to the brain. |
| Authors | Li-Mei Lin, Daniel M Sciubba, Gary L Gallia, Jeffrey Sosnowski, Jon D Weingart
(Affiliation: Department of Neurosurgery, Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer 8-161, Baltimore, MD 21287, USA.)
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| Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 105
Issue 1
Pg. 273-6
(Apr 2007)
ISSN: 0090-8258 United States |
| PMID | 17292458
(Publication Type: Case Reports, Journal Article)
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| Chemical References |
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| Topics |
- Adenocarcinoma, Clear Cell
(chemically induced, pathology, secondary)
- Adult
- Brain Neoplasms
(chemically induced, secondary)
- Diethylstilbestrol
(adverse effects)
- Female
- Humans
- Maternal Exposure
- Pregnancy
- Prenatal Exposure Delayed Effects
- Vaginal Neoplasms
(chemically induced, pathology)
|
