Effective treatment of multifocal aggressive fibromatosis with low-dose chemotherapy.

Abstract

Desmoid tumor (aggressive fibromatosis), as a member of a group of borderline neoplasms, is a rare tumor of fibroblastic origin that remains difficult to treat. Treatments with surgery, radiotherapy and different medical protocols including interferon (IFN)-alpha, hormonal agents such as tamoxifen (anti-estrogen) as well as non-steroidal anti-inflammatory drugs and low-dose antineoplastic agents have been reported. In this report we describe a new patient with multifocal aggressive fibromatosis who was successfully treated with low-dose chemotherapy consisting of methotrexate and vinblastine.

• Authors: Kudret Caglar, Hasan Ozyönüm, Minel Akalin, Sevim Balci
• Journal: The Turkish journal of pediatrics (Turk J Pediatr) 2006 Oct-Dec Vol. 48 Issue 4 Pg. 365-8 ISSN: 0041-4301 [Print] Turkey
• PMID: 17290575 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Vinblastine
• Methotrexate

Topics

• Adolescent
• Antimetabolites, Antineoplastic (administration & dosage, therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Biopsy
• Female
• Fibromatosis, Aggressive (drug therapy, pathology)
• Follow-Up Studies
• Humans
• Methotrexate (administration & dosage, therapeutic use)
• Time Factors
• Treatment Outcome
• Vinblastine (administration & dosage, therapeutic use)