| Abstract | 11beta-hydroxysteroid dehydrogenase (11beta-HSD) is the key enzyme of glucocorticoid metabolism, which catalyzes interconversion of corticosterone and 11-dehydrocorticosterone in rat. The activity of 11beta-HSD in kidneys of rats with inherited stress-induced arterial hypertension (ISIAH) was significantly (p < 0.05) higher than that in WAG rats. The opposite was observed in the activity of liver 11beta-HSD. Under stress condition no changes in the kidney 11beta-HSD activity of both strains were observed, but the liver 11beta-HSD activity in ISIAH rats was significantly (p < 0.05) higher as compared to basal level and stressed WAG rats. It is possible that the features of the 11beta-HSD activity in ISIAH rats may reflect the hypertensive status of ISIAH rats. |
| Authors | O P Cherkasova |
| Journal | Biomedit͡sinskai͡a khimii͡a
(Biomed Khim)
2006 Nov-Dec
Vol. 52
Issue 6
Pg. 568-75 Russia (Federation) |
| PMID | 17288248
(Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Corticosterone
- 11-dehydrocorticosterone
- 11-beta-Hydroxysteroid Dehydrogenases
|
| Topics |
- 11-beta-Hydroxysteroid Dehydrogenases
(metabolism)
- Animals
- Corticosterone
(analogs & derivatives, metabolism)
- Hypertension
(enzymology, genetics)
- Kidney
(enzymology)
- Liver
(enzymology)
- Rats
- Rats, Inbred Strains
- Species Specificity
- Stress
(enzymology, genetics)
|
