Isolation, structure determination, and anti-cancer activity of apoptolidin D.

Abstract	The isolation, characterization, and preliminary biological activity of apoptolidin D, a new apoptolidin that exhibits anti-proliferative activity against H292 human lung carcinoma cells at nanomolar concentrations, are reported. Its equilibration with isoapoptolidin D and characterization of the latter are also described. [structure: see text].
Authors	Paul A Wender, Kate E Longcore
Journal	Organic letters (Org Lett) Vol. 9 Issue 4 Pg. 691-4 (Feb 15 2007) ISSN: 1523-7060 [Print] United States
PMID	17286376 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References	Antineoplastic Agents Macrolides apoptolidin
Topics	Antineoplastic Agents (chemical synthesis, isolation & purification, pharmacology) Cell Line, Tumor Cell Proliferation (drug effects) Chromatography, High Pressure Liquid Fermentation Humans Kinetics Macrolides (chemical synthesis, isolation & purification, pharmacology) Magnetic Resonance Spectroscopy Nocardia (metabolism)

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