Abstract | CONTEXT: INTRODUCTION: PATIENT AND METHODS: RESULTS: Serum ALP and osteocalcin and urinary hydroxyproline were increased. Radiographs showed widespread, symmetric hyperostosis in the limbs where bone scintigraphy demonstrated enhanced radionuclide uptake. Iliac crest histology revealed accelerated skeletal turnover. No mutations were detected in the three genes examined. Three years of therapy with 70 mg alendronate orally once weekly improved symptoms, radiographic abnormalities, and biochemical markers. CONCLUSIONS:
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Authors | Suat Simsek, Natalja M Basoski, Nathalie Bravenboer, Xiafang Zhang, Steven Mumm, Michael P Whyte, J Coen Netelenbos |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 92
Issue 5
Pg. 1897-901
(May 2007)
ISSN: 0021-972X [Print] United States |
PMID | 17284635
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adaptor Proteins, Signal Transducing
- Biomarkers
- Bone Density Conservation Agents
- Osteoprotegerin
- Receptor Activator of Nuclear Factor-kappa B
- SQSTM1 protein, human
- Sequestosome-1 Protein
- TNFRSF11A protein, human
- TNFRSF11B protein, human
- Alkaline Phosphatase
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Topics |
- Adaptor Proteins, Signal Transducing
(genetics)
- Adult
- Alkaline Phosphatase
(blood, metabolism)
- Biomarkers
- Bone Density Conservation Agents
(therapeutic use)
- Bone and Bones
(diagnostic imaging, metabolism)
- Female
- Fingers
(diagnostic imaging, pathology)
- Humans
- Inflammation
(pathology)
- Osteoprotegerin
(genetics)
- Pain
(etiology)
- Periostitis
(complications)
- Radiography
- Radionuclide Imaging
- Receptor Activator of Nuclear Factor-kappa B
(genetics)
- Sequestosome-1 Protein
- Syndrome
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