| Abstract | INTRODUCTION: This study was conducted in order to determine if glucosamine sulphate taken by patients as treatment for chronic joint pain influences the fasting blood levels of cholesterol and triglycerides. MATERIALS AND METHODS: A 3 months', post-marketing, randomised, double-blinded, placebo-controlled, clinical trial was performed with parallel groups of 66 patients over 40 years of age with joint pain of long duration receiving either recommend dosage (1500 mg per day) of glucosamine sulphate or placebo. The primary outcome measures were cholesterol levels (total cholesterol, LDL (low density lipoprotein)-cholesterol and HDL (high density lipoprotein)-cholesterol) and triglycerides in fasting blood (plasma levels). Secondary outcome measures were self reported side-effects. RESULTS: No significant differences between the glucosamine sulphate group and the placebo group with respect to cholesterol and triglycerides were observed. There were no differences between the treatment groups with respect to side-effects. CONCLUSION: This study demonstrates that glucosamine sulphate does not significantly influence blood levels of cholesterol or triglycerides. |
| Authors | Keld Østergaard, Thomas Hviid, Jacob L Hyllested-Winge
(Affiliation: Slidgigtinstituttet A/S, Ishøj. ostergaard at slidgigt.dk)
|
| Journal | Ugeskrift for laeger
(Ugeskr Laeger)
Vol. 169
Issue 5
Pg. 407-10
(Jan 29 2007)
ISSN: 1603-6824 Denmark |
| Vernacular Title | Glukosaminsulfat påvirker ikke plasmaniveauer af kolesterol og triglycerider--en klinisk undersøgelse. |
| PMID | 17280633
(Publication Type: English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Cholesterol, HDL
- Cholesterol, LDL
- Triglycerides
- Glucosamine
- Cholesterol
|
| Topics |
- Adult
- Aged
- Arthralgia
(drug therapy)
- Cholesterol
(blood)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Double-Blind Method
- Female
- Glucosamine
(administration & dosage, adverse effects)
- Humans
- Male
- Middle Aged
- Triglycerides
(blood)
|
