| Abstract | A 4-month-old girl diagnosed with familial hemophagocytic lymphohistiocytosis underwent a matched unrelated, umbilical cord blood transplant. Six weeks later she developed severe acute autoimmune hemolytic anemia and thrombocytopenia requiring multiple transfusions. This was refractory to high-dose steroid and intravenous immunoglobulin, but did respond to Rituximab (anti-CD20 monoclonal antibody) 375 mg/m2. Hemolysis recurred after steroid tapering but responded to a second course of Rituximab. This case report highlights the difficulty in managing posttransplant autoimmune hemolytic anemia. |
| Authors | Mohamed Radhi, Steve Rumelhart, David Tatman, Fred Goldman
(Affiliation: Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA. mohamed-radhi at uiowa.edu)
|
| Journal | Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology
(J Pediatr Hematol Oncol)
Vol. 29
Issue 2
Pg. 125-7
(Feb 2007)
ISSN: 1077-4114 United States |
| PMID | 17279011
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Adrenal Cortex Hormones
- Antibodies, Monoclonal
- Immunoglobulins, Intravenous
- Immunologic Factors
- rituximab
|
| Topics |
- Adrenal Cortex Hormones
(therapeutic use)
- Anemia, Hemolytic, Autoimmune
(drug therapy, etiology)
- Antibodies, Monoclonal
(therapeutic use)
- Cord Blood Stem Cell Transplantation
(adverse effects)
- Female
- Fetal Blood
(transplantation)
- Humans
- Immunoglobulins, Intravenous
(therapeutic use)
- Immunologic Factors
(therapeutic use)
- Infant
- Lymphohistiocytosis, Hemophagocytic
(therapy)
- Thrombocytopenia
(drug therapy, etiology)
|
