Antiviral effect of a synthetic brassinosteroid on the replication of vesicular stomatitis virus in Vero cells.

Abstract

The antiviral mode of action of the synthetic brassinosteroid (22S,23S)-3beta-bromo-5alpha,22,23-trihydroxystigmastan-6-one (6b) against replication of vesicular stomatitis virus (VSV) in Vero cells was investigated. Time-related experiments showed that 6b mainly affects a late event of the virus growth cycle. Virus adsorption, internalisation and early RNA synthesis are not the target of the inhibitory action. Results obtained indicate that the antiviral compound adversely affects virus protein synthesis and viral mature particle formation.

• Authors: Carina Romanutti, Viviana Castilla, Celia E Coto, Mónica B Wachsman
• Journal: International journal of antimicrobial agents (Int J Antimicrob Agents) Vol. 29 Issue 3 Pg. 311-6 (Mar 2007) ISSN: 0924-8579 [Print] Netherlands
• PMID: 17275263 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• DNA, Viral
• RNA, Viral
• Steroids

Topics

• Animals
• Antiviral Agents (chemical synthesis, chemistry, pharmacology)
• Base Sequence
• Chlorocebus aethiops
• DNA, Viral (genetics)
• Molecular Structure
• RNA, Viral (biosynthesis, genetics)
• Steroids (chemical synthesis, chemistry, pharmacology)
• Vero Cells
• Vesicular stomatitis Indiana virus (drug effects, genetics, physiology)
• Virus Replication (drug effects)