Abstract | OBJECTIVE: METHODS AND RESULTS: In this study, we investigated whether oral BH4 treatment might slow the progression of atherosclerosis using hypercholesterolemic apolipoprotein E-knockout mice. We report that ingesting BH4 in drinking water is sufficient to inhibit atherogenesis in mice. Furthermore, we report that BH4 treatment improves endothelial dysfunction and attenuates increased mRNA expression of NADPH oxidase components, as well as a number of inflammatory factors, such as LOX-1 and MCP-1, in the aortas of apolipoprotein E- knockout mice. CONCLUSION:
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Authors | Yoshiyuki Hattori, Sachiko Hattori, Xi Wang, Hiroko Satoh, Nobuo Nakanishi, Kikuo Kasai |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 27
Issue 4
Pg. 865-70
(Apr 2007)
ISSN: 1524-4636 [Electronic] United States |
PMID | 17272747
(Publication Type: Journal Article)
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Chemical References |
- Apolipoproteins E
- Inflammation Mediators
- RNA, Messenger
- Superoxides
- Biopterin
- sapropterin
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Topics |
- Administration, Oral
- Animals
- Aorta
(metabolism)
- Apolipoproteins E
(deficiency)
- Atherosclerosis
(etiology, metabolism, pathology, physiopathology)
- Biopterin
(administration & dosage, analogs & derivatives, pharmacokinetics, pharmacology)
- Disease Progression
- Endothelium, Vascular
(drug effects, physiopathology)
- Hypercholesterolemia
(complications)
- Immunohistochemistry
- Inflammation Mediators
(antagonists & inhibitors)
- Mice
- Mice, Knockout
- RNA, Messenger
(antagonists & inhibitors)
- Superoxides
(metabolism)
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