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Glucosamine sulfate promotes osteoblastic differentiation of MG-63 cells via anti-inflammatory effect.

Abstract
Glucosamine sulfate (SGlc) has been known to be effective in controlling osteoarthritis (OA) symptoms in several clinical studies. However, the mechanisms of this positive effect of SGlc in human OA still remain elusive. Therefore, first, the effects of SGlc on the differentiation of osteoblast-like MG-63 cells were investigated. Our results demonstrate that SGlc can increase ALP activity, collagen synthesis, osteocalcin secretion, and mineralization in osteoblastic cells in vitro. Furthermore, it was observed that SGlc exhibited anti-inflammatory effect on production of TNF-alpha, IL-1beta, and PGE(2) in macrophage, RAW264.7 cells. In conclusion, these results suggest that SGlc can promote cell differentiation in cultured MG-63 osteoblast cells via anti-inflammatory effect.
AuthorsMoon Moo Kim, Eresha Mendis, Niranjan Rajapakse, Se-Kwon Kim
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 17 Issue 7 Pg. 1938-42 (Apr 1 2007) ISSN: 0960-894X [Print] England
PMID17270442 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents
  • Interleukin-1beta
  • Tumor Necrosis Factor-alpha
  • Dinoprostone
  • Glucosamine
Topics
  • Anti-Inflammatory Agents (pharmacology)
  • Cell Differentiation
  • Cell Line, Tumor
  • Chemistry, Pharmaceutical (methods)
  • Dinoprostone (metabolism)
  • Dose-Response Relationship, Drug
  • Drug Design
  • Drug Screening Assays, Antitumor
  • Glucosamine (pharmacology)
  • Humans
  • Interleukin-1beta (metabolism)
  • Macrophages (metabolism)
  • Molecular Conformation
  • Osteoblasts (cytology, metabolism)
  • Tumor Necrosis Factor-alpha (metabolism)

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