Abstract | BACKGROUND: AIM: METHODS: Patients with chronic laryngitis were recruited. The frequency and severity of reflux and laryngeal symptoms were scored and laryngitis graded by laryngoscopy. All patients underwent esophagogastroduodenoscopy and 24-h ambulatory pH monitoring before receiving lansoprazole 30 mg b.d. for 8 weeks. RESULTS: The prevalence of gastro-oesophageal reflux disease was 65.6% (21 of 32). Based on positive pH test, the prevalence was 25% (eight of 32). The change in laryngeal symptom score and laryngitis grade was significantly higher in GERD compared with non- GERD patients (P = 0.010 for both). The proportion of patients with marked/moderate improvement in laryngeal symptoms were significantly higher in patients with reflux (14 of 21, 67%) compared to those without reflux (two of 11, 18%; P = 0.026). CONCLUSIONS:
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Authors | C S Qua, C H Wong, K Gopala, K L Goh |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 25
Issue 3
Pg. 287-95
(Feb 01 2007)
ISSN: 0269-2813 [Print] England |
PMID | 17269990
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Anti-Ulcer Agents
- Proton Pump Inhibitors
- Proton Pumps
- Lansoprazole
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Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
(therapeutic use)
- Adult
- Anti-Ulcer Agents
(therapeutic use)
- Cohort Studies
- Female
- Gastroesophageal Reflux
(complications)
- Humans
- Lansoprazole
- Laryngitis
(etiology)
- Male
- Middle Aged
- Prospective Studies
- Proton Pump Inhibitors
- Proton Pumps
(therapeutic use)
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