PEGylated dendritic architecture for development of a prolonged drug delivery system for an antitubercular drug.

Abstract

The present study was aimed at developing and exploring the use of PEGylated poly (propylene imine) dendritic architecture for the delivery of an anti-tuberculosis drug, rifampicin. For this study, PEGylated poly(propylene imine) dendritic architecture was synthesized and loaded with rifampicin. Various physicochemical and physiological parameters UV, IR, NMR, TEM, DSC, drug entrapment, drug release and hemolytic toxicity of both PEGylated and non-PEGylated systems were determined and compared. The PEGylation of the systems was found to have increased their drug-loading capacity, reduced their drug release rate and hemolytic toxicity. The systems were found suitable for prolonged delivery of rifampicin.

• Authors: P Vijayaraj Kumar, Hrushikesh Agashe, Tathagata Dutta, Narendra K Jain
• Journal: Current drug delivery (Curr Drug Deliv) Vol. 4 Issue 1 Pg. 11-9 (Jan 2007) ISSN: 1567-2018 [Print] United Arab Emirates
• PMID: 17269913 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antitubercular Agents
• Aziridines
• Delayed-Action Preparations
• Dendrimers
• propyleneimine
• Rifampin

Topics

• Antitubercular Agents (administration & dosage, chemistry)
• Aziridines (chemistry)
• Calorimetry, Differential Scanning (methods)
• Delayed-Action Preparations (administration & dosage, chemistry)
• Dendrimers (chemistry)
• Drug Delivery Systems (methods)
• Drug Stability
• Drug Storage
• Erythrocytes (drug effects)
• Humans
• Magnetic Resonance Spectroscopy (methods)
• Microscopy, Electron, Transmission (methods)
• Models, Chemical
• Particle Size
• Rifampin (administration & dosage, chemistry)
• Spectrophotometry, Infrared (methods)
• Technology, Pharmaceutical (methods)
• Temperature
• Time Factors
• Ultraviolet Rays