| Abstract | INTRODUCTION: Sweet's syndrome, one of the neutrophilic dermatoses, is idiopathic in most cases. In 10-20% of cases it is paraneoplastic, associated with a solid tumour or haematological malignancy. An association with carcinoma of the bronchus has been only rarely described. CASE REPORT: We report the case of a 56 year old man who presented with Sweet's syndrome two months before the diagnosis of a squamous cell carcinoma of the bronchus. The dermatosis responded well to corticosteroids. The progress of the tumour was favourable, with stabilisation following 3 courses of chemotherapy and local radiotherapy. DISCUSSION: This case report updates this rare association and underlines the importance of undertaking appropriate thoracic investigations in the presence of this dermatosis. A paraneoplastic secretion of interleukin-8, GM-CSF and/or G-CSF by the bronchial tumour cells facilitating the recruitment of neutrophils, particularly in the skin, may account for the pathophysiology of this condition. |
| Authors | A Van Denhove, N Freymond, S Isaac, K Marrou, B Balme, F Gormand, B Guibert, Y Pacheco, G Devouassoux
(Affiliation: Service de Pneumologie, Centre Hospitalier Lyon Sud, HCL, France.)
|
| Journal | Revue des maladies respiratoires
(Rev Mal Respir)
Vol. 24
Issue 1
Pg. 77-80
(Jan 2007)
ISSN: 0761-8425 France |
| Vernacular Title | Syndrome de Sweet révélant un carcinome bronchique épidermoïde. Cancer bronchique et dermatose neutrophilique. |
| PMID | 17268370
(Publication Type: Case Reports, English Abstract, Journal Article)
|
| Topics |
- Bronchial Neoplasms
(complications)
- Carcinoma, Non-Small-Cell Lung
(complications)
- Carcinoma, Squamous Cell
(complications)
- Humans
- Lung Neoplasms
(complications)
- Male
- Middle Aged
- Paraneoplastic Syndromes
(etiology)
- Sweet Syndrome
(etiology)
|
