Hepatoprotective effects of Chai-Hu-Ching-Kan-Tang on acetaminophen-induced acute liver injury in rats.

Abstract	Chai-Hu-Ching-Kan-Tang (CHCKT) is one of the traditional Chinese medicine prescriptions commonly used to treat liver diseases. In this study, we evaluated the hepatoprotective effects of aqueous CHCKT extract at various concentrations (125, 250 and 500 mg/kg body weight) on acetaminophen (APAP)-induced acute liver injury in rats. Results showed that CHCKT treatments significantly decreased the level of serum glutamic oxaloacetic transaminase (sGOT) and glutamic pyruvic transaminase (sGPT) in APAP-treated groups. CHCKT also significantly decreased the level of lipid peroxides and increased the activity of antioxidant enzymes (i.e. SOD and GPx). Histopathological observation further confirmed the hepatoprotective activity of CHCKT as indicated by the amelioration in the central necrosis and fatty changes of the liver after APAP induction. Interestingly, the hepatoprotective activity of CHCKT at concentrations 125~500 mg/kg appeared to be as good as 12.5 mg/kg silymarin (a commercial hepatoprotective agent). Taken together, these results suggest that aqueous extract of CHCKT possesses potent hepatoprotective effects agianst APAP-induced liver injury in rats.
Authors	Tzu-Hsiang Lin, Lean-Teik Ng, Feng-Lin Yen, Chun-Ching Lin
Journal	The American journal of Chinese medicine (Am J Chin Med) Vol. 35 Issue 1 Pg. 69-79 ( 2007) ISSN: 0192-415X [Print] Singapore
PMID	17265552 (Publication Type: Journal Article)
Chemical References	Analgesics, Non-Narcotic Drugs, Chinese Herbal Lipid Peroxides chai-hu-ching-kan-tang Acetaminophen Glutathione Peroxidase Superoxide Dismutase Aspartate Aminotransferases Alanine Transaminase
Topics	Acetaminophen (adverse effects) Alanine Transaminase (blood) Analgesics, Non-Narcotic (adverse effects) Animals Aspartate Aminotransferases (blood) Chemical and Drug Induced Liver Injury Drugs, Chinese Herbal (therapeutic use) Glutathione Peroxidase (metabolism) Lipid Peroxides (metabolism) Liver (metabolism, pathology) Liver Diseases (drug therapy, prevention & control) Male Random Allocation Rats Rats, Wistar Superoxide Dismutase (metabolism)

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