[Advances in protective effects of vagal nerve and acetylcholine against ischemia injury to myocardium].

Abstract

Ischemic heart disease severely endangers health of mankind. Recent advances displayed that myocardial ischemia was relative to a reduction of vagal tone and an increase of sympathetic tone. This article, which is from the view of the change of modulation of cardiac vagal nerve during ischemic heart disease, protective effects of vagal nerve/acetylcholine to ischemic myocardium and the potential way of signal transduction in ischemic preconditioning/postconditioning, summarizes the advances of study on protective effects and mechanisms of vagal nerve and acetylcholine against ischemia injury of myocardium. This review will administer to penetrating understanding to pathogenesis, prevention and cure of ischemic heart disease, and develop the new way for prevention and cure of it.

• Authors: Wei-Jin Zang, Jun Lu, Dong-Ling Li, Bing Jia, Xiao-Li Xu, Lei Sun
• Journal: Sheng li ke xue jin zhan [Progress in physiology] (Sheng Li Ke Xue Jin Zhan) Vol. 37 Issue 4 Pg. 292-6 (Oct 2006) ISSN: 0559-7765 [Print] China
• PMID: 17262960 (Publication Type: English Abstract, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review)

Chemical References

• Acetylcholine

Topics

• Acetylcholine (physiology)
• Humans
• Myocardial Ischemia
• Vagus Nerve (physiology)